Tg(Gpx1)41Dkd
Transgene Detail

Summary

• Symbol: Tg(Gpx1)41Dkd
• Name: transgene insertion 41, Dipak K Das
• MGI ID: MGI:3783719
• Synonyms: GPx-Tg, Tg(MGP)-41
• Transgene: Tg(Gpx1)41Dkd Location: unknown
• Alliance: Tg(Gpx1)41Dkd page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Gpx1)41Dkd expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Gpx1 (MGI:104887)

• Mutation details: The transgene construct contains a 5.3 kb fragment of genomic DNA encoding the entire mouse Gpx1 gene with about 2 kb of 5' flanking sequence. The construct was microinjected into fertilized B6C3F1 x B6C3F1 oocytes. Two lines with additional copies of the Gpx1 gene were generated and line 41 was chosen for the original study. Increased Gpx1 mRNA expression was detected in RNA blots in eye, brain, lung, muscle, spleen, tongue, and most dramatically in heart of transgenic animals. Gpx1 activity in heart was found to be increased by 500% relative to wild-type controls. Activity was increased in other tissues also. (J:127782)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:127782 Yoshida T, et al., Transgenic mice overexpressing glutathione peroxidase are resistant to myocardial ischemia reperfusion injury. J Mol Cell Cardiol. 1996 Aug;28(8):1759-67
• All: 3 reference(s)