Tg(ACTB-SOD2)66Ysh
Transgene Detail

Summary

• Symbol: Tg(ACTB-SOD2)66Ysh
• Name: transgene insertion 66, Ye-Shih Ho
• MGI ID: MGI:3783732
• Synonyms: MnSOD-Tg, Tg(HMS)66, TgHMS66
• Transgene: Tg(ACTB-SOD2)66Ysh Location: unknown
• Alliance: Tg(ACTB-SOD2)66Ysh page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(ACTB-SOD2)66Ysh expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SOD2 (6648)

  Sod2	(MGI:98352)

• Mutation details: cDNA for human mitochondrial superoxide dismutase (MnSOD or SOD2) was placed downstream of a human beta actin promoter and a 5' flanking sequence. The construct contained intron 1 sequence of the human beta actin gene to allow RNA splicing to occur. Line 66 was established. RNA blot analysis showed a 1.4 kb human MnSOD mRNA expressed in the mouse heart. Enzymatic activity in the heart is increased 325% relative to wild-type. (J:127776)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:127776 Chen Z, et al., Overexpression of MnSOD protects against myocardial ischemia/reperfusion injury in transgenic mice. J Mol Cell Cardiol. 1998 Nov;30(11):2281-9
• All: 15 reference(s)