Rcan1^tm1Emar
Targeted Allele Detail

Summary

• Symbol: Rcan1^tm1Emar
• Name: regulator of calcineurin 1; targeted mutation 1, Eulalia Marti
• MGI ID: MGI:3783735
• Gene: Rcan1 Location: Chr16:92188839-92263057 bp, - strand Genetic Position: Chr16, 53.6 cM
• Alliance: Rcan1^tm1Emar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132745
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 6 through part of exon 7 was replaced with a neo cassette. The absence of protein was confirmed by western blot analysis on cultured primary neuron extracts. (J:132745)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rcan1 Mutation: 26 strains or lines available

References

• Original: J:132745 Porta S, et al., RCAN1 (DSCR1) increases neuronal susceptibility to oxidative stress: a potential pathogenic process in neurodegeneration. Hum Mol Genet. 2007 May 1;16(9):1039-50
• All: 6 reference(s)