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Pbx1tm2Mlc
Targeted Allele Detail
Summary
Symbol: Pbx1tm2Mlc
Name: pre B cell leukemia homeobox 1; targeted mutation 2, Micheal L Cleary
MGI ID: MGI:3783739
Gene: Pbx1  Location: Chr1:167946933-168259839 bp, - strand  Genetic Position: Chr1, 75.95 cM
Alliance: Pbx1tm2Mlc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:132963
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsES cells containing one null Pbx1tm1Mlc allele were used in a second targeting event. The remaining wild-type allele was targeted by inserting a loxP site upstream of exon 3 and a loxP site and hygromycin-GFP fusion cassette downstream of exon 3. (J:132963)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pbx1 Mutation:  40 strains or lines available
References
Original:  J:132963 Sanyal M, et al., B-cell development fails in the absence of the Pbx1 proto-oncogene. Blood. 2007 May 15;109(10):4191-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory