Pbx1^tm2.1Mlc
Targeted Allele Detail

Summary

• Symbol: Pbx1^tm2.1Mlc
• Name: pre B cell leukemia homeobox 1; targeted mutation 2.1, Micheal L Cleary
• MGI ID: MGI:3783740
• Gene: Pbx1 Location: Chr1:167946933-168259839 bp, - strand Genetic Position: Chr1, 75.95 cM
• Alliance: Pbx1^tm2.1Mlc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132963
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre mediated recombination of Pbx1^tm2Mlc resulted in deletion of exon 3. (J:132963)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pbx1 Mutation: 40 strains or lines available

References

• Original: J:132963 Sanyal M, et al., B-cell development fails in the absence of the Pbx1 proto-oncogene. Blood. 2007 May 15;109(10):4191-9
• All: 1 reference(s)