Bad^tm2Meg
Targeted Allele Detail

Summary

• Symbol: Bad^tm2Meg
• Name: BCL2-associated agonist of cell death; targeted mutation 1.1, Michael E Greeberg
• MGI ID: MGI:3783745
• Synonyms: Bad^S155A
• Gene: Bad Location: Chr19:6919229-6929267 bp, + strand Genetic Position: Chr19, 5.1 cM
• Alliance: Bad^tm2Meg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:133563
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: An exon 3 that contains a nucleotide substitution that results in the amino acid substitution of serine with alanine at position 155 (p.S155A) was knocked into the locus. An FRT site flanked neomycin resistance gene cassette was inserted into intron 4. The neo cassette was removed by germ-line, flp-mediated recombination. The mutation prevents phosphoralyzation of residue 155 in the encoded protein. (J:133563)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bad Mutation: 25 strains or lines available

References

• Original: J:133563 Danial NN, et al., Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med. 2008 Feb;14(2):144-53
• All: 4 reference(s)