mt-Rnr2^m1Dwa
Spontaneous Allele Detail

Summary

• Symbol: mt-Rnr2^m1Dwa
• Name: mitochondrially encoded 16S rRNA; mutation 1, Douglas C Wallace
• MGI ID: MGI:3783752
• Synonyms: CAP^R
• Gene: mt-Rnr2 Location: ChrMT:1094-2675 bp, + strand Genetic Position: ChrMT, Syntenic
• Alliance: mt-Rnr2^m1Dwa page

Mutation origin

• Strain of Origin: C3H/An

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: The mouse cell line 501-1 (derived from A9 line) carried a T-to-C transition at position 2433 at the 3' end of Rnr2. This mutation results in a chloramphenicol resistance phenotype in the cells. (J:133576)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any mt-Rnr2 Mutation: 0 strains or lines available

Notes

Mice chimeric for this allele exhibit ophthalmological abnormalities, including congenital cataracts, decreased retinal function and hamaratomas of the optic nerve (J:133576).

References

• Original: J:133576 Sligh JE, et al., Maternal germ-line transmission of mutant mtDNAs from embryonic stem cell-derived chimeric mice. Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14461-6
• All: 2 reference(s)