Rspo2^tm1Hoka
Targeted Allele Detail

Summary

• Symbol: Rspo2^tm1Hoka
• Name: R-spondin 2; targeted mutation 1, Hitoshi Okamoto
• MGI ID: MGI:3783769
• Gene: Rspo2 Location: Chr15:42884190-43034222 bp, - strand Genetic Position: Chr15, 16.73 cM
• Alliance: Rspo2^tm1Hoka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:133600
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The open reading frame was replaced with a lacZ-neo cassette. The absence of transcript was confirmed by RT-PCR on E13.5 embryo extracts. This is a null allele as well as reporter allele with lacZ expression that recapitulates endogenous expression. (J:133600)

Expression

In Mice Carrying this Mutation:	49 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rspo2 Mutation: 20 strains or lines available

References

• Original: J:133600 Aoki M, et al., R-spondin2 expression in the apical ectodermal ridge is essential for outgrowth and patterning in mouse limb development. Dev Growth Differ. 2008 Feb;50(2):85-95
• All: 2 reference(s)