Nupr1^tm1Jlio
Targeted Allele Detail

Summary

• Symbol: Nupr1^tm1Jlio
• Name: nuclear protein transcription regulator 1; targeted mutation 1, Juan Lucio Iovanna
• MGI ID: MGI:3784016
• Synonyms: p8^-
• Gene: Nupr1 Location: Chr7:126222418-126224642 bp, - strand Genetic Position: Chr7, 69.21 cM, cytoband F4
• Alliance: Nupr1^tm1Jlio page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:133728
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 is replaced by a neomycin cassette in reverse orientation. Loss of protein product in the pancreas was confirmed by Western blot analysis. (J:133728)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nupr1 Mutation: 11 strains or lines available

References

• Original: J:133728 Vasseur S, et al., p8-deficient fibroblasts grow more rapidly and are more resistant to adriamycin-induced apoptosis. Oncogene. 2002 Mar 7;21(11):1685-94
• All: 20 reference(s)