Tg(GFAP-APOE_i4)22Hol
Transgene Detail
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Symbol: |
Tg(GFAP-APOE_i4)22Hol |
Name: |
transgene insertion 22, David M Holtzman |
MGI ID: |
MGI:3784296 |
Synonyms: |
GFAP-apoE4 line 22, Tg(GFAP-APOE*4)22Hol |
Transgene: |
Tg(GFAP-APOE_i4)22Hol Location: unknown
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Alliance: |
Tg(GFAP-APOE_i4)22Hol page
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Strain of Origin: |
C57BL/6 and CBA
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(GFAP-APOE_i4)22Hol expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
APOE (348) |
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Mutation details: The transgene contains sequence encoding human apolipoprotein E4 isoform under the control of the human glial fibrillary acidic protein (GFAP) promoter. Five lines were created (lines 1, 3, 11, 19 and 22). The pattern of expression of the human apolipoprotein E3 isoform (APOE3) transgenic product in these mice follows the endogenous mouse APOE and GFAP expression patterns in the brain. Human APOE3 is immunodetectable in glia and neuropil in developing and adult mutant mice.
(J:93487)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:93487 Sun Y, et al., Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins. J Neurosci. 1998 May 1;18(9):3261-72 |
All: |
1 reference(s) |
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