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Tg(GFAP-APOE_i4)22Hol
Transgene Detail
Summary
Symbol: Tg(GFAP-APOE_i4)22Hol
Name: transgene insertion 22, David M Holtzman
MGI ID: MGI:3784296
Synonyms: GFAP-apoE4 line 22, Tg(GFAP-APOE*4)22Hol
Transgene: Tg(GFAP-APOE_i4)22Hol  Location: unknown  
Alliance: Tg(GFAP-APOE_i4)22Hol page
Transgene
origin
Strain of Origin:  C57BL/6 and CBA
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(GFAP-APOE_i4)22Hol expresses 1 gene
 
Mutation detailsThe transgene contains sequence encoding human apolipoprotein E4 isoform under the control of the human glial fibrillary acidic protein (GFAP) promoter. Five lines were created (lines 1, 3, 11, 19 and 22). The pattern of expression of the human apolipoprotein E3 isoform (APOE3) transgenic product in these mice follows the endogenous mouse APOE and GFAP expression patterns in the brain. Human APOE3 is immunodetectable in glia and neuropil in developing and adult mutant mice. (J:93487)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:93487 Sun Y, et al., Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins. J Neurosci. 1998 May 1;18(9):3261-72
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory