Tg(GFAP-APOE_i4)#Hol
Transgene Detail

Summary

• Symbol: Tg(GFAP-APOE_i4)#Hol
• Name: transgene insertion, David M Holtzman
• MGI ID: MGI:3784297
• Synonyms: Tg(GFAP-APOE*4)Hol
• Transgene: Tg(GFAP-APOE_i4)#Hol Location: unknown
• Alliance: Tg(GFAP-APOE_i4)#Hol page

Transgene origin

• Strain of Origin: C57BL/6 and CBA

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(GFAP-APOE_i4)#Hol expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APOE (348)

  Apoe	(MGI:88057)

• Mutation details: The transgene contains sequence encoding human apolipoprotein E4 isoform under the control of the human glial fibrillary acidic protein (GFAP) promoter. Five lines were created (lines 1, 3, 11, 19 and 22). The pound symbol (#) is used when no line number is specified or multiple lines are used. The pattern of expression of the human apolipoprotein E3 isoform (APOE3) transgenic product in these mice follows the endogenous mouse APOE and GFAP expression patterns in the brain. Human APOE3 is immunodetectable in glia and neuropil in developing and adult mutant mice. (J:93487)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

J:53613 and J:127846 use a combination of lines 11 and 22.

References

• Original: J:93487 Sun Y, et al., Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins. J Neurosci. 1998 May 1;18(9):3261-72
• All: 10 reference(s)