Wdr1^Gt(XN462)Byg
Gene trapped Allele Detail

Summary

• Symbol: Wdr1^Gt(XN462)Byg
• Name: WD repeat domain 1; gene trap XN462, BayGenomics
• MGI ID: MGI:3784953
• Synonyms: Wdr1^gt
• Gene: Wdr1 Location: Chr5:38684149-38720265 bp, - strand Genetic Position: Chr5, 20.63 cM
• Alliance: Wdr1^Gt(XN462)Byg page

Mutation origin

• Mutant Cell Line: XN462
• Germline Transmission: Earliest citation of germline transmission: J:134092
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT2Lxf Vector Type: gene trap
• Mutation details: A gene trap vector containing a betageo expression cassette inserted into intron 2, 6.61 kb downstream of exon 2. (J:134092)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XN462	CC326435 ; (MGI Seq Detail)	5' RACE	Chr5:38718422-38718911 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  15 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wdr1 Mutation: 41 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:134092 Kile BT, et al., Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopenia. Blood. 2007 Oct 1;110(7):2371-80
• All: 2 reference(s)