Mmp14^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Mmp14^m1Btlr
• Name: matrix metallopeptidase 14 (membrane-inserted); mutation 1 Bruce Beutler
• MGI ID: MGI:3784968
• Synonyms: cartoon
• Gene: Mmp14 Location: Chr14:54669055-54679913 bp, + strand Genetic Position: Chr14, 27.79 cM
• Alliance: Mmp14^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation is a T-to-C transition at nucleotide position 1642 (Genbank Accession NM_008608) resulting in replacement of serine by proline at amino acid position 422 of the protein (S422P), near the middle of the hemopexin-like domain, which is involved in homodimer formation and mediates association with and cleavage of CD44. (J:133626)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mmp14 Mutation: 44 strains or lines available

References

• Original: J:133626 Du X, et al., Cartoon is an allele of Mmp14 associated with craniofacial anomolies, retarded growth and reduced viability. MGI Direct Data Submission. 2008
• All: 1 reference(s)