Rspo1^tm1Mcch
Targeted Allele Detail

Summary

• Symbol: Rspo1^tm1Mcch
• Name: R-spondin 1; targeted mutation 1, Marie-Christine Chaboissier
• MGI ID: MGI:3784976
• Gene: Rspo1 Location: Chr4:124880223-124902892 bp, + strand Genetic Position: Chr4, 57.96 cM
• Alliance: Rspo1^tm1Mcch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:133933
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ gene and neo cassette were inserted into exon 3. The absence of transcript was confirmed by RT-PCR analysis on E13.5 embryo extracts. (J:133933)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rspo1 Mutation: 21 strains or lines available

References

• Original: J:133933 Chassot AA, et al., Activation of beta-catenin signaling by Rspo1 controls differentiation of the mammalian ovary. Hum Mol Genet. 2008 May 1;17(9):1264-77
• All: 15 reference(s)