Psca^tm1Witt
Targeted Allele Detail

Summary

• Symbol: Psca^tm1Witt
• Name: prostate stem cell antigen; targeted mutation 1, Owen N Witte
• MGI ID: MGI:3784994
• Gene: Psca Location: Chr15:74586688-74588914 bp, + strand Genetic Position: Chr15, 34.26 cM
• Alliance: Psca^tm1Witt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:133908
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: All of exon 2 and a portion of exon 3 were replaced with a neo cassette. The absence of transcript was confirmed by RT-PCR from prostate and bladder extracts. (J:133908)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Psca Mutation: 13 strains or lines available

References

• Original: J:133908 Moore ML, et al., Deletion of PSCA increases metastasis of TRAMP-induced prostate tumors without altering primary tumor formation. Prostate. 2008 Feb 1;68(2):139-51
• All: 1 reference(s)