Tg(Ttn-Ighmbp2)45Cx
Transgene Detail

Summary

• Symbol: Tg(Ttn-Ighmbp2)45Cx
• Name: transgene insertion 45, Gregory A Cox
• MGI ID: MGI:3785076
• Synonyms: TgMI
• Transgene: Tg(Ttn-Ighmbp2)45Cx Location: unknown
• Alliance: Tg(Ttn-Ighmbp2)45Cx page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ttn-Ighmbp2)45Cx expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ighmbp2 (MGI:99954)

• Tg(Ttn-Ighmbp2)45Cx expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ttn (MGI:98864)

• Mutation details: A cDNA sequence encoding the full mouse Ighmbp2 was placed under the control of a modified 5.87 kb mouse genomic fragment containing the Ttn promoter, non-coding Ttn exon 1, intron 1, and 30 base pairs of Ttn exon 2 lacking the start codon. Transgene expression was limited to the heart and skeletal muscles as confirmed by RT-PCR expression using Ighmbp2 exon 1. (J:102748)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:102748 Maddatu TP, et al., Dilated cardiomyopathy in the nmd mouse: transgenic rescue and QTLs that improve cardiac function and survival. Hum Mol Genet. 2005 Nov 1;14(21):3179-89
• All: 1 reference(s)