Tg(Thy1-SOD1*G93A)T3Hgrd
Transgene Detail
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Symbol: |
Tg(Thy1-SOD1*G93A)T3Hgrd |
Name: |
transgene insertion T3, Casper Hoogenraad |
MGI ID: |
MGI:3785090 |
Synonyms: |
Thy1.2-G93A |
Transgene: |
Tg(Thy1-SOD1*G93A)T3Hgrd Location: unknown
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Alliance: |
Tg(Thy1-SOD1*G93A)T3Hgrd page
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Thy1-SOD1*G93A)T3Hgrd expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
SOD1 (6647) |
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Mutation details: The transgene construct contains a modified regulatory region of the murine thy1.2 gene (extending from the promoter to the intron following exon 4, excluding exon 3 and its flanking introns), upstream of a mutant human superoxide dismutase cDNA sequence (G93A-SOD1) harboring a single amino acid substitution of glycine to alanine at codon 93. Transgene expression throughout the brain and spinal cord was determined by western blot. Line T3 was characterized further.
(J:134095)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:134095 Jaarsma D, et al., Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice. J Neurosci. 2008 Feb 27;28(9):2075-88 |
All: |
2 reference(s) |
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