Slco1b2^tm1Cdk
Targeted Allele Detail

Summary

• Symbol: Slco1b2^tm1Cdk
• Name: solute carrier organic anion transporter family, member 1b2; targeted mutation 1, Curtis D Klaassen
• MGI ID: MGI:3785252
• Gene: Slco1b2 Location: Chr6:141575244-141632372 bp, + strand Genetic Position: Chr6, 72.57 cM, cytoband G1
• Alliance: Slco1b2^tm1Cdk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:133919
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 3 was disrupted by insertion of a floxed neo cassette. Low levels of a truncated mRNA transcript are detected. Western blot analysis confirmed the absence of protein in homozygous livers. Therefore, this is a null allele. (J:133919)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slco1b2 Mutation: 47 strains or lines available

References

• Original: J:133919 Lu H, et al., Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR. Toxicol Sci. 2008 May;103(1):35-45
• All: 1 reference(s)