Tg(Thy1-SOD1*G93A)T1Hgrd
Transgene Detail

Summary

• Symbol: Tg(Thy1-SOD1*G93A)T1Hgrd
• Name: transgene insertion T1, Casper Hoogenraad
• MGI ID: MGI:3785266
• Transgene: Tg(Thy1-SOD1*G93A)T1Hgrd Location: unknown
• Alliance: Tg(Thy1-SOD1*G93A)T1Hgrd page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-SOD1*G93A)T1Hgrd expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SOD1 (6647)

  Sod1	(MGI:98351)

• Mutation details: The transgene construct contains a modified regulatory region of the murine thy1.2 gene (extending from the promoter to the intron following exon 4, excluding exon 3 and its flanking introns), upstream of a mutant human superoxide dismutase cDNA sequence (G93A-SOD1) harboring a single amino acid substitution of glycine to alanine at codon 93. Transgene expression throughout the brain and spinal cord was determined by western blot. Line T1 was used for further studies. (J:134095)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:134095 Jaarsma D, et al., Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice. J Neurosci. 2008 Feb 27;28(9):2075-88
• All: 1 reference(s)