Gpam^tm1.1Dali
Targeted Allele Detail

Summary

• Symbol: Gpam^tm1.1Dali
• Name: glycerol-3-phosphate acyltransferase, mitochondrial; targeted mutation 1.1, Daniel Linden
• MGI ID: MGI:3785384
• Gene: Gpam Location: Chr19:55056067-55115666 bp, - strand Genetic Position: Chr19, 50.81 cM
• Alliance: Gpam^tm1.1Dali page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134068
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutation: Intragenic deletion
• Mutation details: Germ line, cre-mediated recombination was used to remove exons 3 and 4. The absence of protein product was confirmed by western blot analysis on liver mitochondria extracts, however, some activity is detected in microsomes. (J:130468)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpam Mutation: 53 strains or lines available

References

• Original: J:134068 Yazdi M, et al., The role of mitochondrial glycerol-3-phosphate acyltransferase-1 in regulating lipid and glucose homeostasis in high-fat diet fed mice. Biochem Biophys Res Commun. 2008 May 16;369(4):1065-70
• All: 2 reference(s)