Heyl^tm1Gess
Targeted Allele Detail

Summary

• Symbol: Heyl^tm1Gess
• Name: hairy/enhancer-of-split related with YRPW motif-like; targeted mutation 1, Manfred Gessler
• MGI ID: MGI:3785385
• Gene: Heyl Location: Chr4:123127349-123143663 bp, + strand Genetic Position: Chr4, 57.41 cM
• Alliance: Heyl^tm1Gess page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:133699
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 5, which encompass nearly all of the coding sequence, were replaced with an in frame lacZ and floxed neo cassette. The absence of transcript expression was confirmed by whole mount in situ hybridization on E12.5 embryos. This allele is a reporter and knockout allele. (J:133699)

Expression

In Mice Carrying this Mutation:

5 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Heyl Mutation: 17 strains or lines available

References

• Original: J:133699 Fischer A, et al., Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition. Circ Res. 2007 Mar 30;100(6):856-63
• All: 6 reference(s)