Mus81^tm1Esse
Targeted Allele Detail

Summary

• Symbol: Mus81^tm1Esse
• Name: MUS81 structure-specific endonuclease subunit; targeted mutation 1, Jeroen Essers
• MGI ID: MGI:3785405
• Synonyms: Efemp2/Mus81^tm1Esse, Fibulin-4^R
• Gene: Mus81 Location: Chr19:5532589-5538461 bp, - strand Genetic Position: Chr19, 4.34 cM
• Alliance: Mus81^tm1Esse page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:133703
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 through 10 of Mus81 were replaced with a neo cassette. Reduction in expression of transcripts for both Mus81 and the neighboring gene Efemp2 was confirmed by quantitative RT-PCR on embryonic fibroblasts extracts. (J:133703)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mus81 Mutation: 31 strains or lines available

References

• Original: J:133703 Hanada K, et al., Perturbations of vascular homeostasis and aortic valve abnormalities in fibulin-4 deficient mice. Circ Res. 2007 Mar 16;100(5):738-46
• All: 7 reference(s)