Rgs5^tm1Cbet
Targeted Allele Detail

Summary

• Symbol: Rgs5^tm1Cbet
• Name: regulator of G-protein signaling 5; targeted mutation 1, Christer Betsholtz
• MGI ID: MGI:3785528
• Synonyms: rgs5^GFP
• Gene: Rgs5 Location: Chr1:169483070-169523367 bp, + strand Genetic Position: Chr1, 76.84 cM, cytoband H2
• Alliance: Rgs5^tm1Cbet page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134210
• Parent Cell Line: F1H4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 2 through the end of the coding region in exon 5 was replaced with a GFP reporter gene and floxed neo cassette. The absence of transcript was confirmed by qantitative RT-PCR on P6 brain extracts. This is a reporter and null allele. (J:134210)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rgs5 Mutation: 21 strains or lines available

References

• Original: J:134210 Nisancioglu MH, et al., Generation and characterization of rgs5 mutant mice. Mol Cell Biol. 2008 Apr;28(7):2324-31
• All: 7 reference(s)