Gad1^{tm1(Gria2)Mony}
Targeted Allele Detail

Summary

• Symbol: Gad1^{tm1(Gria2)Mony}
• Name: glutamate decarboxylase 1; targeted mutation 1, Hannah Monyer
• MGI ID: MGI:3785546
• Synonyms: GAD-GluR-B
• Gene: Gad1 Location: Chr2:70392109-70432358 bp, + strand Genetic Position: Chr2, 41.63 cM, cytoband D
• Alliance: Gad1^{tm1(Gria2)Mony} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134013
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: A cassette containing rat cDNA for Gria2 with with 200 bp of the 5' untranslated region and the Q/R site edited in the flip configuration, an IRES, a lacZ reporter gene and a neo selection marker was knocked into exon 2 upstream of the translation initiation codon. Gria2 expression is detected in GABAergic interneurons by immunocytohistochemistry. This is a reporter and knockin allele. (J:134013)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gad1 Mutation: 65 strains or lines available

References

• Original: J:134013 Fuchs EC, et al., Genetically altered AMPA-type glutamate receptor kinetics in interneurons disrupt long-range synchrony of gamma oscillation. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3571-6
• All: 1 reference(s)