Robo4^tm1Kzh
Targeted Allele Detail

Summary

• Symbol: Robo4^tm1Kzh
• Name: roundabout guidance receptor 4; targeted mutation 1, Kang Zhang
• MGI ID: MGI:3785556
• Synonyms: Robo4^AP
• Gene: Robo4 Location: Chr9:37313198-37325319 bp, + strand Genetic Position: Chr9, 20.76 cM
• Alliance: Robo4^tm1Kzh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:133680
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 4 were replaced with a human placental alkaline phosphatase gene and a self-excising neo cassette. These exons encode the immunoglobin repeats required for Slit binding. Western blot analysis confirmed the absence of endogenous expression. This is a null and reporter allele. (J:133680)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Robo4 Mutation: 89 strains or lines available

References

• Original: J:133680 Jones CA, et al., Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability. Nat Med. 2008 Apr;14(4):448-53
• All: 11 reference(s)