Tcrg^tm1.1Dhr
Targeted Allele Detail

Summary

• Symbol: Tcrg^tm1.1Dhr
• Name: T cell receptor gamma chain; targeted mutation 1.1, David Raulet
• MGI ID: MGI:3785563
• Synonyms: Tcrg^delta43
• Gene: Tcrg Location: Chr13:19362212-19540646 bp, + strand Genetic Position: Chr13, cytoband A2-A3

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:133974
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Tcrg^tm1.1Dhr involves 3 genes/genome features (Tcrg, Trgv4, Trgv3) View all
• Mutation details: The variable regions 3 and 4 were replaced with a floxed neo cassette and a variable region 4 and 2 with a 5' loxP site. Transient cre expression in ES cells was used to remove the neo cassette and the inserted variable region 4 and 2 leaving only the endogenous variable region 2. (J:133974)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcrg Mutation: 1 strain or line available

References

• Original: J:133974 Xiong N, et al., Gene placement and competition control T cell receptor gamma variable region gene rearrangement. J Exp Med. 2008 Apr 14;205(4):929-38
• All: 1 reference(s)