Cry2^tm1Hnos
Targeted Allele Detail

Summary

• Symbol: Cry2^tm1Hnos
• Name: cryptochrome circadian regulator 2; targeted mutation 1, Hiroshi Nose
• MGI ID: MGI:3785706
• Gene: Cry2 Location: Chr2:92233991-92264388 bp, - strand Genetic Position: Chr2, 51.01 cM, cytoband E
• Alliance: Cry2^tm1Hnos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134129
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 7 through 9 were replaced with a cassette that contained an En2-derived splice acceptor, and an IRES-lacZ-neo fusion gene. (J:134129)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cry2 Mutation: 42 strains or lines available

References

• Original: J:134129 Masuki S, et al., Reduced alpha-adrenoceptor responsiveness and enhanced baroreflex sensitivity in Cry-deficient mice lacking a biological clock. J Physiol. 2005 Jul 1;566(Pt 1):213-24
• All: 8 reference(s)