Tg(Col1a2-cre/ERT,-ALPP)7Cpd
Transgene Detail

Summary

• Symbol: Tg(Col1a2-cre/ERT,-ALPP)7Cpd
• Name: transgene insertion 7, Christopher P Denton
• MGI ID: MGI:3785760
• Synonyms: Col1a2 Cre-ER, Col1a2-Cre-ER(T), Col1a2CreERT, Tg(Col1a2-cre/ERT)7Cpd, Tg(Col1a2-cre/ESR1)71Pcn, Tg(Col1a2-cre/ESR1)7Cpd
• Transgene: Tg(Col1a2-cre/ERT,-ALPP)7Cpd Location: unknown
• Alliance: Tg(Col1a2-cre/ERT,-ALPP)7Cpd page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Col1a2-cre/ERT,-ALPP)7Cpd expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Col1a2

• Mutation details: The Col1a2 enhancer was used to drive fibroblast-specific expression of a cre/ERT fusion followed by an IRES-human placental alkaline-phosphatase reporter. Two lines were created (lines 7 and 8) and line 7 was used in subsequent analysis. (J:134447)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Col1a2 (species not specified) Summary of all recombinase alleles driven by Col1a2. Comparative matrix view of recombinase activities

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available

References

• Original: J:134447 Zheng B, et al., Ligand-dependent genetic recombination in fibroblasts : a potentially powerful technique for investigating gene function in fibrosis. Am J Pathol. 2002 May;160(5):1609-17
• All: 108 reference(s)