Tg(Camk2a-ESR1/Disc1*)2698.1Sva
Transgene Detail

Summary

• Symbol: Tg(Camk2a-ESR1/Disc1*)2698.1Sva
• Name: transgene insertion 2698.1, Alcino J Silva
• MGI ID: MGI:3785794
• Synonyms: DISC-cc, LBD^G521R-DISC1-cc
• Transgene: Tg(Camk2a-ESR1/Disc1*)2698.1Sva Location: unknown
• Alliance: Tg(Camk2a-ESR1/Disc1*)2698.1Sva page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Camk2a-ESR1/Disc1*)2698.1Sva expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Disc1 (MGI:2447658)

• Mutation details: The transgene construct is composed of a mouse a-calmodulin kinase II promoter, a hybrid intron in the 5' untranslated leader, a HA virus-tag sequence, and a mutant form of the estrogen ligand biding domain (LBDG521R) cDNA fused 5' to a truncated mouse DISC1 cDNA (DISC1-cc; encoding the C-terminal protein residues 671-852), and a polyA sequence. Upon tamoxifen induction of fusion gene expression, the LBDG521R-DISC1-cc fusion protein is directed to the cortex, hippocampus, striatum, and cerebellum by the CaMKIIa promoter. Immunohistochemical expression of mutant protein is observed in the forebrain in the branches and cytoplasm of neurons. (J:127235)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:127235 Li W, et al., Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice. Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18280-5
• All: 4 reference(s)