Tlx3^tm1(cre)Qima
Targeted Allele Detail

Summary

• Symbol: Tlx3^tm1(cre)Qima
• Name: T cell leukemia, homeobox 3; targeted mutation 1, Qiufu Ma
• MGI ID: MGI:3789185
• Synonyms: Rnx-Cre, Tlx3^Cre
• Gene: Tlx3 Location: Chr11:33150752-33153589 bp, - strand Genetic Position: Chr11, 19.21 cM, cytoband A5
• Alliance: Tlx3^tm1(cre)Qima page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134327
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Tlx3^tm1(cre)Qima expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tlx3 (MGI:1351209)

• Mutation details: A cre cassette followed by an frt-flanked neo was inserted into exon 2. Germ-line, flp-mediated recombination was used to remove the neo cassette. Cre expression recapitulates endogenous promoter activity. (J:134327)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tlx3 (mouse) Summary of all recombinase alleles driven by Tlx3. Alliance mouse Tlx3 gene page

Disease models

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Tlx3^tm1(cre)Qima

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tlx3 Mutation: 14 strains or lines available

References

• Original: J:134327 Xu Y, et al., Tlx1 and Tlx3 coordinate specification of dorsal horn pain-modulatory peptidergic neurons. J Neurosci. 2008 Apr 9;28(15):4037-46
• All: 9 reference(s)