Tob2^tm1Tya
Targeted Allele Detail

Summary

• Symbol: Tob2^tm1Tya
• Name: transducer of ERBB2, 2; targeted mutation 1, Tadashi Yamamoto
• MGI ID: MGI:3789484
• Gene: Tob2 Location: Chr15:81732473-81742997 bp, - strand Genetic Position: Chr15, 38.26 cM, cytoband E2
• Alliance: Tob2^tm1Tya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134287
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region was replaced with a lacZ gene with a nuclear localization signal and a floxed neo cassette. The absence of protein product was confirmed by western blot analysis on embryonic fibroblast extracts. This is a null allele and a reporter allele. (J:134287)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tob2 Mutation: 23 strains or lines available

References

• Original: J:134287 Ajima R, et al., Osteoporotic bone formation in mice lacking tob2; involvement of Tob2 in RANK ligand expression and osteoclasts differentiation. FEBS Lett. 2008 Apr 16;582(9):1313-8
• All: 3 reference(s)