Hrg^tm1Wja
Targeted Allele Detail

Summary

• Symbol: Hrg^tm1Wja
• Name: histidine-rich glycoprotein; targeted mutation 1, Willi Jahnen-Dechent
• MGI ID: MGI:3789962
• Gene: Hrg Location: Chr16:22769822-22780406 bp, + strand Genetic Position: Chr16, 13.79 cM
• Alliance: Hrg^tm1Wja page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134621
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.8 kb fragment including the translation start site was replaced with a neo cassette via homologous recombination. Immunoblot analysis confirmed the absence of protein in serum from homozygous mice. (J:134621)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hrg Mutation: 33 strains or lines available

References

• Original: J:134621 Tsuchida-Straeten N, et al., Enhanced blood coagulation and fibrinolysis in mice lacking histidine-rich glycoprotein (HRG). J Thromb Haemost. 2005 May;3(5):865-72
• All: 10 reference(s)