Syk^tm1Kuro
Targeted Allele Detail

Summary

• Symbol: Syk^tm1Kuro
• Name: spleen tyrosine kinase; targeted mutation 1, Tomohiro Kurosaki
• MGI ID: MGI:3790068
• Synonyms: Syk^fl
• Gene: Syk Location: Chr13:52737209-52802828 bp, + strand Genetic Position: Chr13, 27.41 cM, cytoband B-C2
• Alliance: Syk^tm1Kuro page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134528
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 9 to 12 were flanked by two loxP sites. A neo cassette used for selection purposes was removed by transient cre-expression in ES cells. (J:134528)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Syk Mutation: 42 strains or lines available

References

• Original: J:134528 Yasuda T, et al., Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion. Immunity. 2008 Apr;28(4):499-508
• All: 1 reference(s)