Gbx2^tm1.2Alj
Targeted Allele Detail

Summary

• Symbol: Gbx2^tm1.2Alj
• Name: gastrulation brain homeobox 2; targeted mutation 1.2, Alexandra L Joyner
• MGI ID: MGI:3790113
• Synonyms: Gbx2^deltahd, Gbx2ⁿ
• Gene: Gbx2 Location: Chr1:89855684-89858898 bp, - strand Genetic Position: Chr1, 45.06 cM, cytoband C5-E1
• Alliance: Gbx2^tm1.2Alj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79431
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Transgenic CMV-cre mice are crossed to Gbx2^tm1.1Alj heterozygotes to delete most of exon 2 producing the Gbx2^tm1.2Alj/⁺ allele. (J:79431)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gbx2 Mutation: 27 strains or lines available

References

• Original: J:79431 Li JY, et al., Changing requirements for Gbx2 in development of the cerebellum and maintenance of the mid/hindbrain organizer. Neuron. 2002 Sep 26;36(1):31-43
• All: 3 reference(s)