Upf2^tm1.1Btp
Targeted Allele Detail

Summary

• Symbol: Upf2^tm1.1Btp
• Name: UPF2 regulator of nonsense transcripts homolog (yeast); targeted mutation 1.1, Bo Torben Porse
• MGI ID: MGI:3790199
• Synonyms: Upf2^delta
• Gene: Upf2 Location: Chr2:5956280-6061514 bp, + strand Genetic Position: Chr2, 3.62 cM
• Alliance: Upf2^tm1.1Btp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134765
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 2 (containing the start methionine codon) and 3 were removed by germ line, cre mediated recombination. This allele is expected to produce a functionally inactive protein lacking several important domains including the N-terminal domain required for Upf1 interaction and nonsense-mediated mRNA decay (NMD). (J:134765)

Expression

In Mice Carrying this Mutation:

156076 assay results 2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Upf2 Mutation: 63 strains or lines available

References

• Original: J:134765 Weischenfeldt J, et al., NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements. Genes Dev. 2008 May 15;22(10):1381-96
• All: 3 reference(s)