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Opn4tm4(DTA)Saha
Targeted Allele Detail
Summary
Symbol: Opn4tm4(DTA)Saha
Name: opsin 4 (melanopsin); targeted mutation 4, Samer Hattar
MGI ID: MGI:3790239
Synonyms: Opn4aDTA, Opn4tm2(DTA)Yau
Gene: Opn4  Location: Chr14:34312575-34322099 bp, - strand  Genetic Position: Chr14, 20.83 cM, cytoband B
Alliance: Opn4tm4(DTA)Saha page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:134780
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn attenuated diphtheria toxin A gene and loxP-flanked neo cassette were inserted immediately downstream of the start methionine codon replacing the coding region through part of exon 9. Expression of this allele results in the ablation of intrinsically photosensitive retinal ganglion cells. (J:134780)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Opn4 Mutation:  33 strains or lines available
References
Original:  J:134780 Guler AD, et al., Melanopsin cells are the principal conduits for rod-cone input to non-image-forming vision. Nature. 2008 May 1;453(7191):102-5
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory