Isl1^tm1Gan
Targeted Allele Detail

Summary

• Symbol: Isl1^tm1Gan
• Name: ISL1 transcription factor, LIM/homeodomain; targeted mutation 1, Lin Gan
• MGI ID: MGI:3790243
• Synonyms: Isl1^lacZ, Isl^lacZ
• Gene: Isl1 Location: Chr13:116434817-116446225 bp, - strand Genetic Position: Chr13, 64.87 cM, cytoband D2.3
• Alliance: Isl1^tm1Gan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134563
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The region between the initiation methionine condon in exon 1 through all of exon 2 was replaced with a lacZ cassette. Expression of LacZ was detected in amacrine cells of the retina. (J:134563)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Isl1 Mutation: 36 strains or lines available

References

• Original: J:134563 Elshatory Y, et al., Expression of the LIM-homeodomain protein Isl1 in the developing and mature mouse retina. J Comp Neurol. 2007 Jul 1;503(1):182-97
• All: 6 reference(s)