Masp1^tm1Tefu
Targeted Allele Detail

Summary

• Symbol: Masp1^tm1Tefu
• Name: MBL associated serine protease 1; targeted mutation 1, Teizo Fujita
• MGI ID: MGI:3790322
• Synonyms: MASP1/3^-
• Gene: Masp1 Location: Chr16:23268167-23339565 bp, - strand Genetic Position: Chr16, 14.23 cM, cytoband B2-B3
• Alliance: Masp1^tm1Tefu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134537
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a neo cassette. The absence of both major protein isoform products was confirmed by western blot analysis. (J:134537)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Masp1 Mutation: 45 strains or lines available

References

• Original: J:134537 Takahashi M, et al., Mannose-binding lectin (MBL)-associated serine protease (MASP)-1 contributes to activation of the lectin complement pathway. J Immunol. 2008 May 1;180(9):6132-8
• All: 10 reference(s)