Cdsn^tm1Mmat
Targeted Allele Detail

Summary

• Symbol: Cdsn^tm1Mmat
• Name: corneodesmosin; targeted mutation 1, Mitsuru Matsumoto
• MGI ID: MGI:3790339
• Gene: Cdsn Location: Chr17:35863025-35868077 bp, + strand Genetic Position: Chr17, 18.7 cM
• Alliance: Cdsn^tm1Mmat page

Cdsn^tm1Mmat/Cdsn^tm1Mmat mice exhibit stratum corneum detachment due to defective desmosome formation

Show the 6 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134613
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 1 and all of exon 2 were replaced with a LacZ-neo fusion gene via homologous recombination. Western blot analysis confirmed the absence of protein in homozygous skin. (J:134613)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdsn Mutation: 21 strains or lines available

References

• Original: J:134613 Matsumoto M, et al., Targeted deletion of the murine corneodesmosin gene delineates its essential role in skin and hair physiology. Proc Natl Acad Sci U S A. 2008 May 6;105(18):6720-4
• All: 1 reference(s)