Del(4Cdkn2a-Cdkn2b)1Brn
Targeted Allele Detail

Summary

• Symbol: Del(4Cdkn2a-Cdkn2b)1Brn
• Name: deletion, Chr 4, Anton Berns 1
• MGI ID: MGI:3790457
• Synonyms: Cdkn2a/Cdkn2b^tm1Brn, Cdkn2a/Cdkn2b^tm1Nki
• Gene: Del(4Cdkn2a-Cdkn2b)1Brn Location: unknown Genetic Position: Chr4, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125189
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(4Cdkn2a-Cdkn2b)1Brn involves 2 genes/genome features (Cdkn2a, Cdkn2b) View all
• Mutation details: Cre-mediated recombination in ES cells with a loxP site and a stop codon inserted in exon 1 alpha of Cdkn2a and with exons 1 and 2 of Cdkn2b replaced with a PGK-hyg cassette as well as a 5' loxP site resulted in a deletion encompassing the promoter of Cdkn2b and the 5' half of the Cdkn2a exon 1a. The absence of p15Ink4b, p16Ink4a and p19Arf protein products was confirmed by western blot analysis on mouse embryonic fibroblasts. (J:125189)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(4Cdkn2a-Cdkn2b)1Brn Mutation: 0 strains or lines available

References

• Original: J:125189 Krimpenfort P, et al., p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a. Nature. 2007 Aug 23;448(7156):943-6
• All: 2 reference(s)