Tg(TcrbBL17)1Lmor
Transgene Detail

Summary

• Symbol: Tg(TcrbBL17)1Lmor
• Name: transgene insertion 1, Lucia Mori
• MGI ID: MGI:3790483
• Synonyms: Vb12, Vbeta12
• Transgene: Tg(TcrbBL17)1Lmor Location: unknown
• Alliance: Tg(TcrbBL17)1Lmor page

Transgene origin

• Strain of Origin: SWR

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(TcrbBL17)1Lmor expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcrb (MGI:98578)

• Mutation details: This transgene is derived from T cell hybridoma line BL17 which encodes the rearrangement Vbeta12-Dbeta1.1-Jbeta1.1 and Cbeta1. The transgene construct was injected into SWR/J fertilized embryos and the mouse line used in this study is referred to as SWR-betaL Tg. This line carries 10 copies of the transgene insertion and expresses high levels of Tcrb mRNA in the spleen. (J:134774)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:134774 Mori L, et al., Expression of a transgenic T cell receptor beta chain enhances collagen-induced arthritis. J Exp Med. 1992 Aug 1;176(2):381-8
• All: 7 reference(s)