Abcc2^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Abcc2^tm1Dgen
• Name: ATP-binding cassette, sub-family member 2; targeted mutation 1, Deltagen
• MGI ID: MGI:3790671
• Synonyms: Abcc2^-, Mrp2^-
• Gene: Abcc2 Location: Chr19:43770747-43826771 bp, + strand Genetic Position: Chr19, 36.67 cM
• Alliance: Abcc2^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134950
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Nucleotides 1886 to 1897 were replaced with a lacZ-neo cassette. The absence of protein product was confirmed by western blot analysis on liver extracts. This is a null allele and a reporter allele. (J:134950)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abcc2 Mutation: 90 strains or lines available

References

• Original: J:134950 Chu XY, et al., Characterization of mice lacking the multidrug resistance protein MRP2 (ABCC2). J Pharmacol Exp Ther. 2006 May;317(2):579-89
• All: 4 reference(s)