Dpysl4^tm1Ttq
Targeted Allele Detail

Summary

• Symbol: Dpysl4^tm1Ttq
• Name: dihydropyrimidinase-like 4; targeted mutation 1, Tam T Quach
• MGI ID: MGI:3790672
• Synonyms: CRMP3^-
• Gene: Dpysl4 Location: Chr7:138665917-138681711 bp, + strand Genetic Position: Chr7, 83.92 cM
• Alliance: Dpysl4^tm1Ttq page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134800
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with an IRES-lacZ-neo cassette. The absence of protein product was confirmed by western blot analysis on hippocampus extracts. This is a null allele and a reporter allele. (J:134800)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Dpysl4 Mutation: 35 strains or lines available

References

• Original: J:134800 Quach TT, et al., CRMP3 is required for hippocampal CA1 dendritic organization and plasticity. FASEB J. 2008 Feb;22(2):401-9
• All: 3 reference(s)