Gt(ROSA)26Sor^{tm1(CAG-Foxo1*)Jcbr}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-Foxo1*)Jcbr}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Jens C Bruning
• MGI ID: MGI:3790725
• Synonyms: FOXO1^delta256
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-Foxo1*)Jcbr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134336
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A transgene containing a Foxo1 cDNA with a truncation at amino acid position 256 followed by an IRES-GFP and driven by the CAGGS promoter (chicken beta actin promoter with CMV enhancers) was inserted into intron 1. An interviening floxed neo-STOP cassette prevents expression of the truncated Foxo1 cDNA except in the presence of cre when the floxed neo-STOP cassette is excised. (J:134336)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:134336 Belgardt BF, et al., PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response. Cell Metab. 2008 Apr;7(4):291-301
• All: 2 reference(s)