Brca1^tm1Thl
Targeted Allele Detail

Summary

• Symbol: Brca1^tm1Thl
• Name: breast cancer 1, early onset; targeted mutation 1, Thomas Ludwig
• MGI ID: MGI:3790741
• Synonyms: Brca1^flex2
• Gene: Brca1 Location: Chr11:101379590-101442781 bp, - strand Genetic Position: Chr11, 65.18 cM, cytoband D
• Alliance: Brca1^tm1Thl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134977
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt-flanked neo cassette with a 3' loxP site was inserted upstream of exon 2 and an additional loxP site was inserted downstream of exon 2. This exon encodes most of the RING finger domain. (J:134977)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Brca1^tm1Thl

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Brca1 Mutation: 114 strains or lines available

References

• Original: J:134977 Shakya R, et al., The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression. Proc Natl Acad Sci U S A. 2008 May 13;105(19):7040-5
• All: 8 reference(s)