Bdkrb1^tm2Bdr
Targeted Allele Detail

Summary

• Symbol: Bdkrb1^tm2Bdr
• Name: bradykinin receptor, beta 1; targeted mutation 2, Michael Bader
• MGI ID: MGI:3790746
• Synonyms: B1B2^-
• Gene: Bdkrb1 Location: Chr12:105570350-105571770 bp, + strand Genetic Position: Chr12, 55.81 cM, cytoband F1
• Alliance: Bdkrb1^tm2Bdr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134859
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region was replaced with a hygro cassette in ES cells containing Bdkrb2^tm1Jfh. The absence of either transcript was confirmed by RT-PCR in stomach, ileum, kidney, heart, brain and lung extracts. (J:134859)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bdkrb1 Mutation: 22 strains or lines available

Notes

ES cells used were established from homozygous B6.129S7/SvBrd-Bdkrb2^tm1Jfh mice. Also note the targeting vector used was identical to the one used to generate Bdkrb1^tm1Bdr.

References

• Original: J:134859 Cayla C, et al., Mice deficient for both kinin receptors are normotensive and protected from endotoxin-induced hypotension. FASEB J. 2007 Jun;21(8):1689-98
• All: 7 reference(s)