Tg(H2-Ea-G6pc2)69Tkay
Transgene Detail

Summary

• Symbol: Tg(H2-Ea-G6pc2)69Tkay
• Name: transgene insertion 69, Thomas Kay
• MGI ID: MGI:3790748
• Transgene: Tg(H2-Ea-G6pc2)69Tkay Location: unknown
• Alliance: Tg(H2-Ea-G6pc2)69Tkay page

Transgene origin

• Strain of Origin: NOD

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(H2-Ea-G6pc2)69Tkay expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	G6pc2 (MGI:1277193)

• Mutation details: This transgene consists of a protein-coding region of glucose-6-phosphatase, catalytic, 2, G6pc2, cloned from the murine NIT-1insulinoma cell line under the control of a 1.8-kb fragment encoding nucleotides -1,903 through -39 of the 5' flanking sequence of the MHC Class II gene, H2-Ea (k allele). Expression of G6pc2 was verified using RT-PCR. Expression levels are low, but sufficient to prevent development of G6pc2-specific T cells in thymus. (J:117352)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:117352 Krishnamurthy B, et al., Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP. J Clin Invest. 2006 Dec;116(12):3258-65
• All: 2 reference(s)