Mfap2^tm1Mech
Targeted Allele Detail

Summary

• Symbol: Mfap2^tm1Mech
• Name: microfibrillar-associated protein 2; targeted mutation 1, Robert P Mecham
• MGI ID: MGI:3790750
• Synonyms: MAGP1^-
• Gene: Mfap2 Location: Chr4:140737735-140743284 bp, + strand Genetic Position: Chr4, 73.31 cM, cytoband D3-E1
• Alliance: Mfap2^tm1Mech page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134343
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 3 to 6, which encode a portion of the signal peptide and nearly half of the coding sequence of the gene, were deleted by homologous recombination. Analysis of the founder lines confirmed that the targeting strategy had successfully given rise to the expected mutant allele. (J:134343)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mfap2 Mutation: 14 strains or lines available

References

• Original: J:134343 Werneck CC, et al., Mice lacking the extracellular matrix protein MAGP1 display delayed thrombotic occlusion following vessel injury. Blood. 2008 Apr 15;111(8):4137-44
• All: 8 reference(s)