Hba^tm1(HBA)Tow
Targeted Allele Detail

Summary

• Symbol: Hba^tm1(HBA)Tow
• Name: hemoglobin alpha chain complex; targeted mutation 1, Timothy Townes
• MGI ID: MGI:3790755
• Synonyms: Hb^A, Hba^halpha
• Gene: Hba Location: unknown Genetic Position: Chr11, cytoband A

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134980
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Hba^tm1(HBA)Tow involves 4 genes/genome features (Hba, Hba-x, Hba-a1 ...) View all
• Hba^tm1(HBA)Tow expresses 3 genes
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBA1 (3039)

  Hba-a1	(MGI:96015)
  Hba-a2	(MGI:96016)

  human

  HBA2 (3040)

  Hba-a1	(MGI:96015)
  Hba-a2	(MGI:96016)

  human

  HBZ (3050)

  Hba-x

  (MGI:96019)

• Hba^tm1(HBA)Tow expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Hba (MGI:96014)

• The complex was replaced with human HBA. Details will be described elsewhere. (J:134980)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Hba Mutation: 10 strains or lines available

References

• Original: J:134980 Wu LC, et al., Correction of sickle cell disease by homologous recombination in embryonic stem cells. Blood. 2006 Aug 15;108(4):1183-8
• All: 126 reference(s)