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Hbbtm3(HBG1,HBB)Tow
Targeted Allele Detail
Summary
Symbol: Hbbtm3(HBG1,HBB)Tow
Name: hemoglobin beta chain complex; targeted mutation 3, Timothy Townes
MGI ID: MGI:3790756
Synonyms: -383 gamma-betaA, Hbbtm3(HBB)Tow
Gene: Hbb  Location: unknown  Genetic Position: Chr7, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:134980
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutations:    Insertion, Intergenic deletion
  Hbbtm3(HBG1,HBB)Tow involves 2 genes/genome features (Hbb-b2, Hbb-b1) View all
 
Hbbtm3(HBG1,HBB)Tow expresses 2 genes
 
Hbbtm3(HBG1,HBB)Tow expression driven by 1 gene
 
Mutation detailsIn ES cells that were homozygous for Hbatm1(HBA)Tow and Hbbtm2(HBG1,HBB*)Tow the human gamma chain and beta chain containing the sickle cell mutation (an A to T transversion in the sixth codon) were replaced with the human gamma chain, beta chain (lacking the sickle cell mutation) and 383 bp of sequence flanking the gamma chain. Cre-mediated recombination removed the floxed hygro cassette. (J:134980)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Hbb Mutation:  47 strains or lines available
References
Original:  J:134980 Wu LC, et al., Correction of sickle cell disease by homologous recombination in embryonic stem cells. Blood. 2006 Aug 15;108(4):1183-8
All:  125 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory